Remotely piloted aircraft (RPA; also known as drone) operators have critical roles in the U.S. Air Force (USAF), ranging from intelligence, surveillance, and reconnaissance missions to delivering weapons on targets for close air support and precision strike operations. The health and wellness of RPA operators are critical to sustaining performance readiness. As a result, the USAF School of Aerospace Medicine was requested by USAF line operator and medical leadership to conduct a field survey to assess for general areas of health-related behaviors (i.e., sleep and exercise; alcohol, tobacco, and caffeine use; common reasons for seeking medical care and mental health support services; and reasons for increased prescription and over-the-counter medication usage). A total of 1,094 MQ-1 Predator/MQ-9 Reaper operators (pilots, sensor operators, and mission intelligence coordinators) from three USAF major commands completed the web-based survey, resulting in a 49% response rate. Statistical analyses were performed to assess for between-group major command differences to quantitative and qualitative items assessing (a) the amount of sleep obtained before work and the frequency of engaging in structured physical exercise throughout the week; (b) the amount, frequency, and increase in consumption of alcohol, tobacco, and caffeine and the reasons for increased consumption; (c) medical conditions worsened by current unit assignment and occupational stress; (d) changes in healthcare utilization since being assigned to Predator/Reaper operations and the reasons for these changes; and finally (e) increases in medication utilization since being assigned to Predator/Reaper operations and the reasons for such increases. A number of recommendations are provided for line and medical leadership for optimizing health for RPA operators. Such recommendations included optimizing work hours and shift work schedules, managing the ergonomic strains inherent in the Predator/Reaper workstations, maintaining sufficient manning for the mission, and embedding mental health providers within line intelligence units, to name a few.