This study investigates the self-reported levels of occupational burnout among 1,094 U.S. Air Force drone operators stationed within the borders of the United States who are supporting a wide range of around-the-clock military surveillance and weapons strike missions across the globe. Data were gathered from a Web-based survey of demographic items and the Maslach Burnout Inventory assessing the facets of occupational burnout (exhaustion, cynicism, and professional efficacy). The overall survey response rate was 49%. Approximately 20% reported high levels of exhaustion, and 11% reported high levels of cynicism, but only 3% reported low levels of professional efficacy. Predictors of exhaustion, as well as between group differences, were identified along with recommendations for performance improvement and mitigating risks to safety.