MQ-1 Predator and MQ-9 Reaper remotely piloted aircraft (RPA; “drones”) operators participate in a diverse range of intelligence, surveillance, and reconnaissance missions, as well as weapon strike missions for close air support to ground troops and aerial sniper missions of enemy combatants. Such operators are required to sustain around-the-clock operations to meet the demand from military leadership requesting weaponized RPAs to support a wide range of global missions. As a result, the health and wellness of the airmen operating such aircraft are paramount to sustaining performance and readiness. As a result, the U.S. Air Force (USAF) School of Aerospace Medicine was requested to conduct a field survey to assess for general areas of health-related behaviors (i.e., sleep and exercise; alcohol, tobacco, and caffeine use; common reasons for seeking medical care and mental health support services; and reasons for increased prescription and over-the-counter medication usage). The purpose of this study was to reevaluate for changes in behavioral health habits among this critical group of military personnel following an earlier study conducted by the USAF School of Aerospace Medicine in 2012. A total of 1161 MQ-1 Predator/MQ-9 Reaper drone operators (pilots, sensor operators, and mission intelligence coordinators) from three USAF major commands within the continental United States completed the web-based survey, resulting in an estimated 40% response rate. Statistical analyses were performed to assess for between-group major command differences to quantitative and qualitative items assessing (a) the amount of sleep obtained before work and the frequency of engaging in structured physical exercise throughout the week; (b) the amount, frequency, and increase regarding consumption of alcohol, tobacco, and caffeine (to include the use of traditional and designer energy drinks) and the reasons for increased consumption; (c) medical conditions worsened by current unit assignment and occupational stress; (d) changes in healthcare utilization (such as medical care, mental health, and alternative health provider services) since being assigned to Predator/Reaper drone operations and the reasons for these changes; and finally (e) increases in medication utilization (i.e., prescription and over-the-counter) since being assigned to Predator/Reaper operations and the reasons for such increases. The results of the study provide empirically based data for shaping line and medical leadership force management strategies geared toward optimizing the health and performance of RPA operators.